AG klinische und translationale Präzisionsonkologie
Every cancer is unique. Precision oncology aims at identifying personalized treatment options through molecular cancer profiling. In our group, we focus on creating reproducible and evidence-based individualized treatment options.
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How patients can benefit through our research
For our ultimate goal to improve treatment strategies we directly translate molecular profiling technologies from routine panel sequencing and immunohistochemistry to multi-omics analyses into clinical care through the weekly Charité molecular tumor conference. Here we bring our latest results from analyzing clinical and molecular data and knowledge of the mechanisms of tumor biology to the table and discuss “real life cases” with a variety of experts.
Research topics
Clinical precision oncology
Since every cancer is unique, reproducible and evidence-based decision-making is a challenge in precision oncology. We collaborate in several national and international working groups to streamline workflows, evidence levels and databases to help translate molecular profiles into personalized treatment using the best available data.
Clinical precision oncology - Selected Publications
Ergebnisse filtern
Ergebnisse 1 bis 10 von insgesamt 17
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Zeitschrift (Journal):Front Oncol. Jahr:2023;
Titel:Targeted treatment in a case series of AR+, HRAS/PIK3CA co-mutated salivary duct carcinoma
Zeitschrift (Journal):Eur J Cancer Jahr:2023;
Titel:Tumour mutational burden and survival with molecularly matched therapy
Zeitschrift (Journal):Nucleic Acids Res. Jahr:2022;
Titel:CIViCdb 2022: evolution of an open-access cancer variant interpretation knowledgebase
Zeitschrift (Journal):BMC Med. Jahr:2022;
Titel:Feasibility and outcome of reproducible clinical interpretation of high-dimensional molecular data: a comparison of two molecular tumor boards
Ergebnisse 1 bis 10 von insgesamt 17
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Translational precision oncology
The combined analysis of clinical and molecular data allows for an in-depth analysis of mechanisms underlying response and resistance to personalized therapies. We aim at harnessing these data to improve understanding of tumor biology and ultimately identify novel treatment strategies.
Translational precision oncology - Selected Publications
Team - Clinical and translational precision oncology
Direktor des Charité Comprehensive Cancer Center, Charité
Ärztlicher Mitarbeiter, Sprecher der Plattform für personalisierte Krebsmedizin - Charité
