Special Seminar: Autoimmunity Checkpoints as Targets in B cell malignancies

Veranstaltung ausschließlich für Fachpublikum

Speaker: Markus Müschen

Abstract:
Unlike other types of cancer, B cell malignancies are susceptible to negative selection and cell death induced by hyperactive signaling from an autoreatictive B cell receptor. While targeted therapy of cancer typically focuses on agents to suppress activity of oncogenes, Markus Müschen and colleagues introduce a new concept of targeted hyperactivation with the goal to trigger autoimmunity checkpoints and cell death in B cell tumors. This approach takes advantage of low energy levels and intrinsic impairment of B cells in utilizing glucose to generate ATP.

References:
Nature 521: 357 - 361 (2015); Nature 542: 479 - 483 (2017); Cell 173: 470 - 484 (2018)

Hosts:
Lorenz Bastian, Clician Scientist
Claudia Baldus, Acting director
Medical Department - Division of Hematologie / Oncolgy
Charité - Universitätsmedizin Berlin
Campus Benjamin Franklin

Markus Müschen will give also a keynote lecture on

"Metabolic Gatekeeper functions of lymphoid transcription factors"

at the CLINICIAN SCIENTIST SYMPOSIUM
30.06.2018, 10:00 - 12:30 Uhr (Session II: Cancer)
Kalkscheune
Johannisstraße 2, 10117 Berlin

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Participant details and registration

Kontakt

Claudia.baldus(at)charite.de

Participant details and registration