Markus Mueschen

Veranstaltung

29.06.2018

Special Seminar: Autoimmunity Checkpoints as Targets in B cell malignancies

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Speaker: Markus Müschen

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Abstract:
Unlike other types of cancer, B cell malignancies are susceptible to negative selection and cell death induced by hyperactive signaling from an autoreatictive B cell receptor. While targeted therapy of cancer typically focuses on agents to suppress activity of oncogenes, Markus Müschen and colleagues introduce a new concept of targeted hyperactivation with the goal to trigger autoimmunity checkpoints and cell death in B cell tumors. This approach takes advantage of low energy levels and intrinsic impairment of B cells in utilizing glucose to generate ATP.

References:
Nature 521: 357 - 361 (2015); Nature 542: 479 - 483 (2017); Cell 173: 470 - 484 (2018)

Hosts:
Lorenz Bastian, Clician Scientist
Claudia Baldus, Acting director
Medical Department - Division of Hematologie / Oncolgy
Charité - Universitätsmedizin Berlin
Campus Benjamin Franklin

 

Markus Müschen will give also a keynote lecture on

"Metabolic Gatekeeper functions of lymphoid transcription factors"

at the CLINICIAN SCIENTIST SYMPOSIUM
30.06.2018, 10:00 - 12:30 Uhr (Session II: Cancer)
Kalkscheune
Johannisstraße 2, 10117 Berlin

Organisatorisches

Referenten:

Markus Müschen
Professor & Chair
Department of Systems Biology
Associated Director of Basic Science
NCI Comprehensive Cancer Center
City of Hope

Veranstalter:

Berlin Institute of Health
Charité & Max Delbrück Center

Zeit:

Friday, Juny 29th, 2018
14:15 - 15:15 (get-together afterwards)

Ort:

Charité - Universitätsmedizin Berlin
Campus Benjamin Franklin
Konferenzraum der Klinik für Psychiatrie, 1. OG
Hindenburgdamm 30, 12203 Berlin

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